Keywords
comparative histology
domestic animals
How to Cite
Abstract
Introduction: The ciliary body, an ocular structure of vital importance in aqueous humor production and lens focusing, varies in morphology and function among different species. The present study compares the anatomical and physiological characteristics of the human ciliary body with those of other species, such as bovine, equine and porcine. Materials and methods: A systematic search of databases was performed, selecting articles dealing with the anatomy and histology of the ciliary body in the mentioned species. Inclusion criteria were used to select relevant studies. Results: Significant differences in the shape, size and distribution of ciliary body structures were revealed, suggesting specific adaptations to the physiological and environmental needs of each one. An analysis of the mechanisms of aqueous humor formation in each was also carried out, highlighting variations in the transporters and ion channels involved. Conclusion: The variations found reflect the evolutionary and adaptive diversity in ocular anatomy. Highlighting the importance of the comparative approach to understand ocular physiology and its clinical and therapeutic implications.
References
Coca-Prados, M., & Escribano, J. (2007). New perspectives in aqueous humor secretion and in glaucoma: The ciliary body as a multifunctional neuroendocrine gland. Progress in Retinal and Eye Research, 26(3), 239-262. https://pubmed.ncbi.nlm.nih.gov/17321191
De Maria, A., Wilmarth, P. A., David, L. L., & Bassnett, S. (2017). Proteomic analysis of the bovine and human ciliary zonule. Investigative Ophthalmology & Visual Science, 58 (1), 573-585. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283081
Delamere, N. A. (2005). Ciliary body and ciliary epithelium. Advances in Organ Biology, 10, 127-148. https://doi.org/10.1016/S1569-2590(05)10005-6
Do, C. W., & To, C. H. (2000). Chloride secretion by bovine ciliary epithelium: A model of aqueous humor formation. Investigative Ophthalmology & Visual Science, 41 (7), 1853-1860. https://pubmed.ncbi.nlm.nih.gov/10845609
Kaser-Eichberger, A., Schrödl, F., Trost, A., Strohmaier, C., Bogner, B., Runge, C., Motloch, K., Bruckner, D., Laimer, M., Schlereth, S. L., Heindl, L. M., & Reitsamer, H. A. (2015). Topography of lymphatic markers in human iris and ciliary body. Investigative Ophthalmology & Visual Science, 56 (8), 4943-4953. https://pubmed.ncbi.nlm.nih.gov/26225635
Kong, C. W., Li, K. K., & To, C. H. (2006). Chloride secretion by porcine ciliary epithelium: New insight into species similarities and differences in aqueous humor formation. Investigative Ophthalmology & Visual Science, 47 (12), 5428-5436. https://pubmed.ncbi.nlm.nih.gov/17122133
Miesfeld, J. B., & Brown, N. L. (2019). Eye organogenesis: A hierarchical view of ocular development. Current Topics in Developmental Biology, 132, 351-393. https://doi.org/10.1016/bs.ctdb.2018.12.008
Miller, T. L., Willis, A. M., Wilkie, D. A., Hoshaw-Woodard, S., & Stanley, J. R. (2001). Description of ciliary body anatomy and identification of sites for transscleral cyclophotocoagulation in the equine eye. Veterinary Ophthalmology, 4 (3), 183-190. https://pubmed.ncbi.nlm.nih.gov/11722782
Patke, A., Young, M. W., & Axelrod, S. (2020). Molecular mechanisms and physiological importance of circadian rhythms. Nature Reviews Molecular Cell Biology, 21 (2), 67-84. https://doi.org/10.1038/s41580-019-0179-2
Pucker, A. D., Carpenter, A. R., McHugh, K. M., & Mutti, D. O. (2014). Guinea pig ciliary muscle development. Optometry and Vision Science, 91 (7), 730-739. https://pubmed.ncbi.nlm.nih.gov/24901488
Remington, L. A., & Goodwin, D. (2021). Clinical anatomy and physiology of the visual system (4th ed.). Elsevier - Health Sciences Division.
Sedacca, K., Samuelson, D., & Lewis, P. (2012). Examination of the anterior uveoscleral pathway in domestic species. Veterinary Ophthalmology, 15 (Suppl. 1), 1-7. https://pubmed.ncbi.nlm.nih.gov/22051120
Villate, M., Méndez, J., & Echeverry, J. (2016). Anatomía quirúrgica del ojo: Revisión anatómica del ojo humano y comparación con el ojo porcino. Morfolia, 8 (3), 21-44. https://revistas.unal.edu.co/index.php/morfolia/article/view/62493
Wullink, B., Pas, H. H., Van der Worp, R. J., Schol, M., Janssen, S. F., Kuijer, R., & Los, L. I. (2018). Type VII collagen in the human accommodation system: Expression in ciliary body, zonules, and lens capsule. Investigative Ophthalmology & Visual Science, 59(2), 1075-1083.
This work is licensed under a Creative Commons Attribution 4.0 International License.