Relationship of telomerase with the processes of cellular senescence and apoptosis
Published 2020-12-07
Keywords
- Telómero,
- Telomerasa,
- Envejecimiento,
- Neoplasias/genética,
- Senescencia Celular
- Telomere,
- Telomerase,
- Aging,
- Neoplasms / genetics,
- Cell Senescence
How to Cite
Copyright (c) 2020 Gabriel Anjos Gil, Luiz Claudio Gonçalves da Silva, Thiago Francisco Neves
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
The telomeres are the free ends of the chromosomes, consisting of non-coding and highly repetitive DNA. They were discovered by Hermann Joseph Muller along with Barbara McClintock during the decade of the 30s of the 20th century, who received the Nobel Prize for such a discovery. Formerly, the etiology of aging pointed to a state, which may have been caused by a gene or by a decline in the physiological system. With the passage of time, it was replaced by the principle that such a factor consists of a multifactorial process resulting from the interaction of cellular and systematic mechanisms. Although many cases of neoplasms are diagnosed in young people, the relationship between older age and cancer is unequivocal. At the cellular level, evidence points to a similarity between these factors. Cellular aging is defined as the lack of somatic division accompanied by loss of function (cellular senescence). While cancer is the result of uncontrolled divisions accompanied by loss or changes of their functions.
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References
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